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Is a generic version of viagra available in many countries.[3] One study on the effect of coenzyme Q10 on erectile dysfunction showed a significant improvement in this sexual function the treatment group compared to placebo (p<0.05).[4] However, most studies are still not able to differentiate between active coenzyme Q10 and the placebo.[5][6] In case of coenzyme Q10 deficiency, the content in serum seems to be lower than those that do not have this deficiency.[8][9] Supplementation of coenzyme Q10 in otherwise healthy men may help with erectile coupon code for generic viagra dysfunction.[10][11] Studies have been conducted on the effects of various forms coenzyme Q10 supplementation.[12][13][14] A Cochrane review on the effects of coenzyme Q10 found a small decrease in erectile function with the use of 300mg CoQ10 per day and a large increase in erectile function with supplementation (1,000mg per day). However, this increase in erectile function may be due to the other factors that supplementing with CoQ10 may have.[15] In regards to its anti-doping status, in January 2014 it was reported that a sample of 464 athletes found the presence of high levels ubiquinone in 34.6% of the samples tested (0.43% by mass of ubiquinone).[16] It might be possible that ubiquinone may an indication of a testosterone deficiency. Uminone (norkosterol) is a metabolite that produced by men after they have consumed a high amount of testosterone, and is also detectable in urine after anabolic agents have been consumed.[17] Uminone is a metabolite of testosterone that can be detected in urine. This can indicate a possible deficiency in testosterone. 6 Interactions with Cancer 6.1. Breast Human and animal studies on the effects of CoQ10 have found that the high concentrations of coenzyme Q10 may be effective in decreasing tumours as it may play a role in suppressing apoptosis[18][19][20] and promoting necrosis.[21][22] Co-enzyme Q10 has shown a role in suppressing angiogenesis and inhibiting cell proliferation (although apoptosis or necrosis can still occur with co-enzyme Q10)[22][23] and reducing metastasis.[24][25] When looking at the interactions between CoQ10 and breast cancer itself, it has been noted that when incubated in a microtubule dependent manner (that is, incubated in the presence of a protein that suppresses microtubules to reduce its influence over cell proliferation and angiogenesis) it can suppress estrogen production to a similar amount that 10ng/mL of CoQ10 can,[26] which suggests that may play a role in suppressing breast cancer.[27] Possible effects on hormones used during cancer treatment where it has potential anti-cancer effects. Coenzyme Q10 supplementation may have an anti-cancer role in this situation. 6.2. Colon The effects of coenzyme Q10 supplementation viagra generic brand on the risk of colon cancer are not well documented, although a meta-analysis and meta-regression suggest that men with a high baseline serum total CoQ10 have a lower risk of developing colon cancer compared to men with a low baseline total CoQ10.[28] When the association between dietary CoQ10 and colon cancer is investigated for men, it was found that the more of coenzyme Q10 in the total diet (versus isolated food sources) the lower risk of colon cancer.[28][29] Possible effects of CoQ10 on colon cancer. supplementation may have an anti-cancer role in this situation. 6.3. Ovarian CoQ10 supplementation has been shown to increase serum levels of fibrinogen and collagen.[30] As the ovary does not make fibrinogen and collagen that is necessary for growth and development, it has been hypothesized that CoQ10 may affect ovarian cancer risk in men via these two molecules.[31] 7 Nutrient-Nutrient Interactions 7.1. Vitamin E Dietary CoQ10 supplementation at 0.38mg per day appears to reduce circulating vitamin E by around 40% over 90 days of supplementation (which is in excess of the requirement general population) to a concentration that is comparable to a typical daily dose and greater than the concentrations that vitamin E can reach from foods (for example: 15mg/kg fresh broccoli or 25mg/kg butter).[32] Similar trends have been noted for beta-carotene and lutein.[33][34] 8 Interactions with Sexuality
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